Effects of varying concentrations of iodine intake on thyroid gland in rats

نوع المستند : المقالة الأصلية

المؤلفون

lecturer of Biological and Geological Sciences Department. Ain Shams University, Faculty of Education

المستخلص

Although iodine is an essential micronutrient needed for the creation of thyroid hormones, too
much of it can cause systemic problems and thyroid malfunction. Elevated iodine levels can
impact multiple organs and interfere with thyroid function. This study investigates the effects of
low and heigh dose of iodine intake on thyroid function, histopathological changes and
biochemical alterations in rats. six healthy control rats (150-200g) as group 1, iodine solution was
ingested orally to 6 rats at dose 500 μg / kg/day as group 2 and iodine solution at dose (1500 μg
/kg/day) was orally administered to 6 rats as group 3. This procedure was performed for 14 days.
At the end of this period thyroid function parameters as T3, T4 and TSH levels were recorded in
blood samples, and thyroid tissues were also examined histopathologically. Results
demonstrated that excessive iodine intake led to thyroidal stress, alterations in thyroxine (T4)
triiodothyronine, (T3) levels and TSH, hyperthyroidism in low dose and hypothyroidism in heigh
dose group were observed, and deteriorative changes in thyroid tissue were detected. These
findings emphasize the possible dangers of excessive iodine intake and highlight the importance
of maintaining balanced iodine levels to avoid thyroid and systemic disorder.

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