The Probable Ameliorative Impact of Royal Jelly Supplementation against Aluminium Chloride-Induced Hepatotoxicity in Adult Rats

نوع المستند : المقالة الأصلية

المؤلفون

Prof of Cell Biology and Histology

10.21608/aash.2025.458241

المستخلص

Background: Aluminium (Al) is the third abundant element on earth, and it is globally considered as a
hidden killer because it is responsible for varied cases of toxicity, health disorders and cancers. Prolonged
exposure to Al resulted in its accumulation in many organs, especially the liver inducing different
deleterious effects. As a dietary supplement, royal jelly (RJ) is gathered and marketed with the promise of
several health benefits due to its compounds Objectives: The current study was performed to explore the
probable impact of RJ on AlCl3-induced hepatotoxicity in rats. Methods: Twenty adult rats were equally
divided into four groups; control group, RJ-treated group, AlCl3-treated group, and RJ+AlCl3-treated
group which were treated for 15 days. Results: Myriad histopathological changes were revealed in the
liver tissues of AlCl3-treated rats including destruction of the regular hepatic structure represented by
damaged cells possessing vacuolated cytoplasm and altered shaped nuclei which displayed signs of pyknosis,
karyorrhexis or karyolysis. Besides, dilatation and congestion of blood vessels. On the other side, a
discernible enhancement of the hepatic tissues' histological architecture was revealed in rats concomitantly
treated with RJ and AlCl3. Conclusion: Based on its anti-inflammatory, anti-apoptotic, and antioxidant
qualities, the current investigation demonstrated that RJ has a protective effect against liver toxicity caused
by AlCl3.

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