The Impact of Common Analgesics on Kidney Function: An Experimental Study on Rats

نوع المستند : المقالة الأصلية

المؤلفون

Lecturer of Zoology, and Biological and Geological Sciences Department

10.21608/aash.2025.458250

المستخلص

This experimental study aimed to evaluate the nephrotoxic and hepatotoxic effects of ibuprofen in male
Wistar rats, which is a widely used nonsteroidal anti-inflammatory drug (NSAID). The animals were divided
into two groups: a control group and a treatment group that received 800 mg/day ibuprofen orally for 12
consecutive days. Biochemical analysis demonstrated a statistically significant increase (p < 0.01) in the serum
urea and creatinine levels in the ibuprofen-treated group, indicating impaired renal function. Additionally,
liver enzymes ALT and AST were markedly elevated, suggesting hepatic injury. Histopathological
examination of the kidney tissues revealed pronounced structural damage, including glomerular atrophy,
tubular necrosis, vacuolation of tubular cells, and congestion of interstitial blood vessels. These findings
provide strong evidence that high-dose, short-term administration of ibuprofen can lead to considerable
functional and structural damage in both the kidneys and liver. This study highlights the necessity of cautious
ibuprofen use, especially in individuals with pre-existing renal or hepatic conditions, and calls for increased
awareness of the potential risks associated with unsupervised NSAID consumption.

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