Oxidative Stress Responses as A Marker of Toxicity in Mice Exposed to Water Deprivation

نوع المستند : المقالة الأصلية

المؤلفون

Lecturer of Zoology, Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University,

10.21608/aash.2025.458253

المستخلص

Water is essential for life, and its deprivation can have severe consequences on human health.
Water scarcity is a growing concern globally, affecting millions of people worldwide.
Understanding the toxic effects of water deprivation on vital organs is crucial for developing
effective strategies to mitigate its impact. This study aimed to investigate the toxicity of water
deprivation on oxidative stress in the kidney, histological changes in the kidney, and genotoxicity
and cytotoxicity in bone marrow. Forty male albino mice were divided into four groups: control
and three water-restricted models (timed, continuous, and intermittent). The results showed
significant decreases in antioxidant enzyme activity and increased oxidative stress in the kidney,
accompanied by histopathological damage, including tubular necrosis and glomerular hyperplasia.
The micronucleus test revealed increased genotoxicity and cytotoxicity in bone marrow, disrupting
erythropoiesis. The findings highlight the detrimental effects of water deprivation on kidney and
bone marrow function, emphasizing the importance of adequate hydration for maintaining organ
integrity. Water deprivation induced significant oxidative stress, renal toxicity, and genotoxic
effects, particularly in the intermittent water restriction group. These results underscore the need
for awareness about the health effects and toxicity of water deficiency. Based on the study's
findings, we recommend prioritizing access to clean drinking water, promoting water conservation
practices, and supporting research into innovative solutions for addressing water scarcity.
Additionally, developing educational programs to raise awareness about the health risks of water
deprivation and fostering community-based initiatives to support affected populations are essential
steps towards mitigating these effects. By acknowledging the toxicity of water deprivation and
taking proactive measures, we can work towards reducing the associated health risks and
promoting overall well-being. Current results have significant implications for public health
policy, emphasizing the need for sustainable water management practices and strategies to protect
vulnerable populations from the adverse effects of water scarcity. By addressing the health risks
associated with water deprivation, we can promote health, well-being, and sustainable
development

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