Histological studies on the effect of soyabeans, as a main ingredient in fast food, on fertility of pubescent male mice

نوع المستند : المقالة الأصلية

المؤلفون

professor of embryology, Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University

10.21608/aash.2025.458256

المستخلص

Soybeans, a widely consumed legume, contain phytoestrogens that mimic estrogen
and may influence reproductive health. With the increasing prevalence of soy-based
ingredients in fast food, concerns have been raised regarding their potential endocrinedisrupting
effects, particularly in males during puberty. This study investigates the
histological impact of a soy-rich diet on the testes of pubescent male mice, providing
insights into its effects on spermatogenesis and testicular morphology.
Eighteen male albino mice were divided into three groups: a control group fed a
standard diet and two experimental groups fed diets containing 50% and 70% soy protein,
respectively, for six weeks. Testicular tissue was collected and analyzed using
histological techniques to assess structural and cellular changes. Results demonstrated
significant alterations in the testes of soy-fed mice, with higher soy intake correlating
with increased disruptions. The 50% soy diet resulted in moderate testicular atrophy,
reduced spermatogenesis, and vacuolization of spermatogenic and Sertoli cells. The 70%
soy diet caused severe degeneration, characterized by extensive germ cell apoptosis,
seminiferous tubule disorganization, and conspicuous alterations of interstitial tissue .
Furthermore, increased vascular congestion and immune cell infiltration suggested an
inflammatory response, possibly induced by oxidative stress.
These findings align with previous research indicating that phytoestrogens can interfere
with male reproductive development. The observed testicular damage suggests that
prolonged exposure to soy-based diets, particularly in fast food, may have adverse effects
on male fertility. Given the global rise in fast-food consumption, further studies are
needed to determine long-term reproductive consequences and to assess potential
reversibility of these effects. This study highlights the importance of dietary awareness
and the need for updated nutritional guidelines to mitigate possible risks associated with
excessive soy intake.

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